Background: Physicians depend on reliable information on the local epidemiology of infection and antibiotic\r\nresistance rates to guide empiric treatment in critically ill patients. As these data are scarce for Central Africa, we\r\nperformed a retrospective analysis of microbiological findings from a secondary care hospital in Gabon.\r\nMethods: Microbiological reports from 2009 to 2012 were used to assess the non-susceptibility rates of the three\r\nmost common isolates from six major types of infections (bloodstream, ear-eye-nose-throat, surgical site, skin and\r\nsoft tissue, urinary tract and wound infection).\r\nResults: A high diversity of pathogens was found, but Staphylococcus aureus was predominant in the majority of\r\ninfections. Overall, the three most prevalent pathogens in children were S. aureus (33.7%), Streptococcus pyogenes (8.1%)\r\nand Escherichia coli (4.5%) and in adults S. aureus (23.5%), E. coli (15.1%) and Klebsiella pneumoniae (7.4%). In total, 5.8%\r\n(n = 19) of all S. aureus isolates were methicillin resistant. The proportion of extended-spectrum beta-lactamase (ESBL)\r\nproducing Enterobacteriaceae was 15.4% (n = 78), 49.4% of all K. pneumoniae were ESBL-producer (n = 42).\r\nConclusion: The high diversity of potential pathogens and high resistance rates in Gram-negative bacteria challenge a\r\nrational empiric use of antibiotics. Countrywide continuous sentinel surveillance is therefore urgently needed
Loading....